Slay the Spire Wiki

Reprogram is an Uncommon Skill for The Defect, which causes it to gain 1 (2) Icon Strength.png Strength and Icon Dexterity.png Dexterity at the cost of losing 1 (2) Icon Focus.png Focus. Upgrading Reprogram increases the attribute changes (both loss and gain) from 1 to 2.

Reprogram can serve as a powerful, reusable source of Icon Strength.png Strength and Icon Dexterity.png Dexterity if you are not using Orbs affected by Icon Focus.png Focus.


  • The focus loss of Reprogram is considered a debuff. As such, Icon Artifact.png Artifacts will negate the focus loss while still providing the strength/dexterity gains. Core Surge and ClockworkSouvenir.png Clockwork Souvenir are reliable sources of Artifacts for The Defect.
  • OrangePellets.png Orange Pellets can be used to remove the focus loss, if you have negative focus. While Artifacts will always block Focus Down, it's only considered a debuff for Orange Pellets if you have negative focus. For instance, if you gain one focus from Defragment and then use Reprogram and go back to zero focus, you cannot undo that loss with Orange Pellets, but if you use Reprogram first and then activate Orange Pellets (keeping in mind that powers will activate before Orange Pellets, so powers that give you focus will still cancel it out), the negative focus will be undone.
  • Plasma.png Plasma orbs are not affected by focus, so Meteor Strike and Fusion work well with Reprogram.
  • If you are committed to using Reprogram and don't mind the Icon Focus.png Focus loss, Hyperbeam has no downsides.
  • All for One can allow you to play several Claws (or other 0-cost attacks) in one turn, allowing you to benefit from the Icon Strength.png Strength gain multiple times.
  • The Icon Dexterity.png Dexterity gained by Reprogram allows Steam Barrier to last longer and yield more Icon Block.png Block for free.
  • Since Reinforced Body applies Icon Block.png Block multiple times, the Icon Dexterity.png Dexterity gained from Reprogram applies multiple times as well.

Update History[]

  • Patch V2.2: Happy Holidays!
    • Reprogram card Focus loss decreased from 2 -> 1.
    • Reprogram+ card changed. Focus loss, Strength, and Dexterity changed from 1 -> 2.
  • Patch V2.0: The Watcher
    • Reprogram card reworked.
  • Weekly Patch 31: Custom Mode
    • Optional UPGRADE_DESCRIPTION added for Pummel, Heavy Blade, Offering, and Reprogram
  • Weekly Patch 27: Hello World
    • This week adds the long anticipated third character into the game!
    • A new character with unique mechanics, keywords, and art.
    • Content: 75 Cards.
BlueEnergy.png Defect Cards BlueEnergy.png