Slay the Spire Wiki

Potions are one-time-use items that can only be used in combat with the exception of Fruit Juice, Entropic Brew, and Blood Potion, which can be used in most scenarios. The player can typically hold up to 3 of them, or 2 on ascension levels 11 and higher. PotionBelt.png Potion Belt increases the number of potion you can hold by 2, which mean you can hold up to 5 potions with it, or 4 on ascension levels 11 and higher.

Using a potion does not require Energy and does not count as playing a card.

When a potion is offered to you, the rarity chances are:

  • 65% for a Common potion.
  • 25% for an Uncommon potion.
  • 10% for a Rare potion.

Obtaining Potions[]

  • Potions are occasionally dropped as a reward after combat. The default chance of a potion dropping is 40% and resets at the start of each Act. If a potion drops, the chance decreases by 10%. If a potion doesn't drop, the chance increases by 10%.
  • Bought at Merchant's Shop
  • If you reached the boss of the first Act, Neow may offer you 3 potions.
  • Some Events offers potions.
    • Lab offers you 3 random potions.
    • The Woman in Blue allows you to buy 1 random potion for 20 gold, 2 for 30 gold, and 3 for 40 gold.
    • Knowing Skull grants you a random potion at the cost of 10% of your HP, with 6 at minimum.
  • Using the card Alchemize creates 1 random potion
  • Obtaining Cauldron.png Cauldron offers you 5 random potions.
  • Obtaining TinyHouse.png Tiny House offers you 1 random potion.
  • EntropicBrew Potion Static.png Entropic Brew fills all your empty potion slots, including its slot, with random potions.
  • Obtaining Sozu.png Sozu prohibits you from obtaining any more potions, including potions obtained from EntropicBrew Potion Static.png Entropic Brew. However, you are still able to use potions you already have on you.

Other Interactions[]

  • We Meet Again! offers you a choice to give Ranwid 1 random potion you have in exchange for a Relic.
  • ToyOrnithopter.png Toy Ornithopter heals 5 HP whenever you use a potion.
  • SacredBark.png Sacred Bark doubles the effectiveness of potions except:
    • Ambrosia.png Ambrosia
    • Blessing Of The Forge temporary.png Blessing of the Forge
    • EntropicBrew Potion Static.png Entropic Brew
    • Elixir.png Elixir
    • GamblersBrew.png Gambler's Brew
    • SmokeBomb.png Smoke Bomb
    • StancePotion.png Stance Potion

List of Potions[]

Icon Name Rarity Effect
Ambrosia Rare (Watcher only) Enter Divinity Stance.
Ancient Potion Uncommon Gain 1 (SacredBark.png 2) Icon Artifact.png Artifact.
Attack Potion Common Add (SacredBark.png 2 copies of) 1 of 3 random Attack cards to your hand, it costs (SacredBark.png They cost) 0 this turn.
Blessing Of The Forge temporary.png
Blessing of the Forge Common Upgrade all cards in your hand for the rest of combat.
Block Potion Common Gain 12 (SacredBark.png 24) Icon Block.png Block.
Blood Potion Common (Ironclad only) Heal for 20% (SacredBark.png 40%) of your Max HP.
Bottled Miracle Common (Watcher only) Add 2 (SacredBark.png 4) Miracles to your hand.
Colorless Potion.png
Colorless Potion Common Choose 1 of 3 random Colorless cards to add (SacredBark.png 2 copies of it) to your hand, it costs (SacredBark.png They cost) 0 this turn.
Cultist Potion Rare Gain 1 (SacredBark.png 2) Icon Ritual.png Ritual.
Cunning Potion Uncommon (Silent only) Add 3 (SacredBark.png 6) Upgraded Shivs to your hand.
Dexterity Potion Common Gain 2 (SacredBark.png 4) Icon Dexterity.png Dexterity.
Distilled Chaos Uncommon Play the top 3 (SacredBark.png 6) cards of your draw pile.
Duplication Potion Uncommon This turn, your next card is (SacredBark.png next 2 cards are) played twice.
Elixir Uncommon (Ironclad only) Exhaust any number of cards in your hand.
Energy Potion Common Gain 2 (SacredBark.png 4) Energy.
Entropic Brew Rare Fill all your empty potion slots with random potions.
Essence of Darkness Rare (Defect only) Channel 1 (SacredBark.png 2) Dark.png Dark for each orb slot.
Essence of Steel Uncommon Gain 4 (SacredBark.png 8) Icon PlatedArmor.png Plated Armor.
Explosive Potion Common Deal 10 (SacredBark.png 20) Damage to all enemies.
Fairy in a Bottle Rare When you would die, heal to 30% (SacredBark.png 60%) of your Max HP instead and discard this potion.
Fear Potion Common Apply 3 (SacredBark.png 6) Icon Vulnerable.png Vulnerable.
Fire Potion Common Deal 20 (SacredBark.png 40) Damage to target enemy.
Flex Potion Common Gain 5 (SacredBark.png 10) Icon Strength.png Strength. At the end of your turn, lose 5 (SacredBark.png 10) Icon Strength.png Strength.
Focus Potion Common (Defect only) Gain 2 (SacredBark.png 4) Icon Focus.png Focus.
Fruit Juice Rare Gain 5 (SacredBark.png 10) Max HP.
Gambler's Brew Uncommon Discard any number of cards, then draw that many.
Ghost In A Jar Rare (Silent only) Gain 1 (SacredBark.png 2) Icon Intangible.png Intangible.
Heart of Iron Rare (Ironclad only) Gain 6 (SacredBark.png 12) Icon Metallicize.png Metallicize.
Liquid Bronze Uncommon Gain 3 (SacredBark.png 6) Icon Thorns.png Thorns.
Liquid Memories Uncommon Choose a card (SacredBark.png 2 cards) in your discard pile and return it (SacredBark.png them) to your hand. It costs (SacredBark.png They cost) 0 this turn.
Poison Potion Common (Silent only) Apply 6 (SacredBark.png 12) Icon Poison.png Poison to target enemy.
Potion of Capacity Uncommon (Defect only) Gain 2 (SacredBark.png 4) Orb slots.
Power Potion Common Add (SacredBark.png 2 copies of) 1 of 3 random Power cards to your hand, it costs (SacredBark.png They cost) 0 this turn.
Regen Potion Uncommon Gain 5 (SacredBark.png 10) Icon Regen.png Regeneration.
Skill Potion Common Add (SacredBark.png 2 copies of) 1 of 3 random Skill cards to your hand, it costs (SacredBark.png They cost) 0 this turn.
Smoke Bomb Rare Escape from a non-boss combat. Receive no rewards.
Snecko Oil Rare Draw 5 (SacredBark.png 10) cards. Randomize the costs of all cards in your hand for the rest of the combat.
Speed Potion Common Gain 5 (SacredBark.png 10) Icon Dexterity.png Dexterity. At the end of your turn, lose 5 (SacredBark.png 10) Icon Dexterity.png Dexterity.
Stance Potion Uncommon (Watcher only) Enter Calm or Wrath.
Strength Potion Common Gain 2 (SacredBark.png 4) Icon Strength.png Strength.
Swift Potion Common Draw 3 (SacredBark.png 6) cards.
Weak Potion Common Apply 3 (SacredBark.png 6) Icon Weak.png Weak.

Update History[]

  • Patch V2.0: The Watcher
    • Ironclad only, Uncommon Potion: Elixir.png Elixir
    • Ironclad only, Rare Potion: HeartofIron.png Heart of Iron
    • Silent only, Uncommon Potion: CunningPotion.png Cunning Potion
    • Defect only, Uncommon Potion: PotionofCapacity.png Potion of Capacity
    • Defect only, Rare Potion: EssenceOfDarkness.png Essence of Darkness
    • Watcher only, Common Potion: BottledMiracle.png Bottled Miracle
    • Watcher only, Uncommon Potion: StancePotion.png Stance Potion
    • Watcher only, Rare Potion: Ambrosia.png Ambrosia
    • Common Potion: Blessing Of The Forge temporary.png Blessing of the Forge
    • Common Potion: Colorless Potion.png Colorless Potion
    • Uncommon Potion: DistilledChaos Potion Static.png Distilled Chaos
    • Uncommon Potion: Duplication Potion Static.png Duplication Potion
    • Uncommon Potion: LiquidMemories.png Liquid Memories
    • Rare Potion: CultistPotion.png Cultist Potion
    • Common potion droprate decreased from 70% -> 65%.
    • Rare potion droprate increased from 5% -> 10%.
    • SneckoOil.png Snecko Oil reworked.
    • BloodPotion.png Blood Potion healing buffed from 10% -> 20%.
    • BloodPotion.png Blood Potion rarity changed from Uncommon -> Common.
    • FairyinaBottle.png Fairy in a Bottle healing buffed from 10% -> 30% HP.
    • FocusPotion.png Focus Potion rarity changed from Uncommon -> Common.
    • GhostInAJar.png Ghost in a Jar rarity changed from Uncommon -> Rare.
    • PoisonPotion.png Poison Potion is now Silent only.
    • Cards/powers/potions that generate now just describe them with a + in their name.
    • Several potions now have updated potion bottle assets.
    • Some potions are rainbow colored now. It's groovy.
      • Affected potions are DistilledChaos Potion Static.png Distilled Chaos, Duplication Potion Static.png Duplication Potion, and EntropicBrew Potion Static.png Entropic Brew.
    • Uncommon potions now have small circle particle effects.
    • Rare potions now have gold sparkly visual effects.
    • Wording updated for several relics, cards, potions, and powers to improve clarity.
    • EntropicBrew Potion Static.png Entropic Brew can now be used outside of combat.
    • Fixed EntropicBrew Potion Static.png Entropic Brew filling potions slots with Sozu.png Sozu.
    • Fixed Mayhem, Havoc, DistilledChaos Potion Static.png Distilled Chaos, and Omniscience sometimes not playing cards if original target is dead.
  • Patch V1.1: The Dealer
    • While the potion popup is open, the potion's tip is now displayed.
    • BloodPotion.png Blood Potion buffed to heal 10% -> 25%.
    • Potion menu is way bigger now (easier to click on for mouse/touchscreen).
    • Top panel gold icon, health icon, potion slots, and modifiers now scale up when hovered.
    • Fixing some grammar and typos in Potion popup text.
    • Tips for potions now show up when hovered in Reward screens and Shops (not just in the Potion panel after acquisition).
    • Fixed issue where up/down on controller in potion drink/discard also navigated to monsters/cards during combat.
    • Knowing Skull event can no longer give you a potion if you have the Sozu.png Sozu relic.
  • Weekly Patch 54: Loop
    • Fixed issue where BloodPotion.png Blood Potion wouldn't heal the player if used immediately after combat.
    • Fixed issue where EntropicBrew Potion Static.png Entropic Brew did not give players potions if used post-combat.
    • Fixed issue where potion seeds weren't persistent on save/load.
    • Fixed issue where ToyOrnithopter.png Toy Ornithopter relic wouldn't trigger outside of combat.
  • Weekly Patch 52: Release Date Price Increase
    • Fixed issue that allowed player to throw SmokeBomb.png Smoke Bomb in some rooms to no effect.
  • Weekly Patch 51: Recursion
    • Muzzle blight was applying twice to LizardTail.png Lizard Tail and FairyinaBottle.png Fairy in a Bottle.
    • Throwing a SmokeBomb.png Smoke Bomb at the Final Act boss no longer crashes the game.
  • Weekly Patch 44: Chrysalis
    • All sources of random temporary card generation in combat (like DeadBranch.png Dead Branch) can no longer generate cards that provide healing.
      • Alchemize is now categorized as a healing card.
    • New tip added to indicate that healing cards cannot be generated randomly during combat.
  • Weekly Patch 42: Reboot
    • Adding card, potion, relic, and heart icons that can appear in tips now. Used on Run History screen.
  • Weekly Patch 41: Chill
    • Fixed SmokeBomb.png Smoke Bomb and Colosseum bug that caused the player to go invisible.
  • Weekly Patch 40: Forethought
    • Removed two outdated tips about potions.
  • Weekly Patch 39: We Meet Again!
    • Potion throw targeting is no longer cancelled via click (you can still drag away or right click to cancel).
  • Weekly Patch 38: Bane
    • We Meet Again! event no longer allows the player to drink or discard the potion.
    • You can now drink FruitJuice.png Fruit Juice in more locations. (FruitJuice.png FRUIT JUICE REVOLUTION)
  • Weekly Patch 37: Darkness
    • Neow's Potion option now opens a reward screen with three potions.
  • Weekly Patch 36: Power Through
    • Fixed bug where We Meet Again! potion removal didn't apply for the left most slot.
  • Weekly Patch 35: Aggregate
    • AttackPotion.png Attack Potion, SkillPotion.png Skill Potion, and PowerPotion.png Power Potion now allow you to choose 1 of 3 cards (buff).
    • Updated SmokeBomb.png Smoke Bomb's use text from Drink -> Throw.
    • Fixed issue where potion targeting failed if the left most enemy was dead (controller only)
    • SmokeBomb.png Smoke Bomb now disables the end turn button so that enemies cannot attack you as you flee.
    • SmokeBomb.png Smoke Bomb no longer trigger Come at Me achievement.
  • Weekly Patch 34: Malaise
    • SneckoOil.png Snecko Oil potion buffed. Draw 2 -> 3 cards.
    • Fixed Save and Quit SmokeBomb.png Smoke Bomb exploit.
    • Using a SmokeBomb.png Smoke Bomb no longer gives the Champion score bonus.
  • Weekly Patch 33: Terror
    • GamblersBrew.png Gambler's Brew will no longer crash if used with no cards in hand.
  • Weekly Patch 32: Face Trader
    • Fixed FairyinaBottle.png Fairy in a Bottle and LizardTail.png Lizard Tail not triggering with Muzzle blight.
  • Weekly Patch 29: TURBO
    • Fixed issue where FairyinaBottle.png Fairy in a Bottle wouldn't heal you if max HP was less than 10.
    • SmokeBomb.png Smoke Bomb now work when fighting monsters in ? rooms.
    • Viewing potions during Discard/Draw Pile view no longer scrolls oddly.
  • Weekly Patch 28: The Ritual
    • Ascension 11 modifier changed. Instead of weakening potions, the player starts with 1 less potion slot.
  • Weekly Patch 27: Hello World
    • This week adds the long anticipated third character into the game!
    • New Uncommon Potion: FocusPotion.png Focus Potion (Defect Only)
  • Weekly Patch 26: Controller Support Testing
    • EntropicBrew Potion Static.png Entropic Brew now works properly with PotionBelt.png Potion Belt as intended.
  • Weekly Patch 25: Building Blocks
    • RegenPotion.png Regen Potion gets an overhaul. It now acts like Icon Poison.png Poison, but Icon Regen.png heals.
    • FruitJuice.png Fruit Juice can now be used outside of combat.
    • FruitJuice.png Fruit Juice will no longer spawn from Alchemize.
    • EntropicBrew Potion Static.png Entropic Brew can no longer spawn Fruit Juice.
    • EntropicBrew Potion Static.png Entropic Brew now spawns potions similarly to Alchemize now (considers rarity).
    • EntropicBrew Potion Static.png Entropic Brew now always gives you potions equal to your potion slot count.
    • SmokeBomb.png Smoke Bomb can no longer be incorrectly used outside of combat. (Can still be discarded)
    • SneckoOil.png Snecko Oil wording fix for high ascension levels.
    • GamblersBrew.png Gambler's Brew gets an updated color/shape.
    • DexterityPotion.png Dexterity Potion shape updated to match StrengthPotion.png Strength Potion.
  • Weekly Patch 24: Potions?!
    • 16 new potions were added and there are now different rarities for potions! We still have a few more goodies coming for potions in a later patch.
    • New Daily Mod: Brewmaster
    • Potion prices are now based on rarity (Common: 50, Uncommon: 75, Rare: 100)
    • Potions can now be character specific.
    • Potions now have rarity: Common, Uncommon, and Rare.
    • New Common Potion: AttackPotion.png Attack Potion.
    • New Common Potion: FearPotion.png Fear Potion.
    • New Common Potion: PowerPotion.png Power Potion.
    • New Common Potion: SkillPotion.png Skill Potion.
    • New Common Potion: SpeedPotion.png Speed Potion.
    • New Common Potion: SteroidPotion.png Steroid Potion.
    • New Rare Potion: EntropicBrew Potion Static.png Entropic Brew.
    • New Rare Potion: FairyinaBottle.png Fairy in a Bottle.
    • New Rare Potion: FruitJuice.png Fruit Juice.
    • New Rare Potion: SmokeBomb.png Smoke Bomb.
    • New Rare Potion: SneckoOil.png Snecko Oil.
    • New Uncommon Potion: BloodPotion.png Blood Potion (Ironclad Only.)
    • New Uncommon Potion: EssenceOfSteel.png Essence of Steel.
    • New Uncommon Potion: GamblersBrew.png Gambler's Brew.
    • New Uncommon Potion: GhostInAJar.png Ghost in a Jar (Silent Only.)
    • New Uncommon Potion: LiquidBronze.png Liquid Bronze.
    • Lowered Potion positions by 2px from top.
    • Updated coloring and image for many potions.
    • You can now discard potions during combat.
    • All potions that were in the game before this patch are Common.
      • Except RegenPotion.png Regen Potion and AncientPotion.png Ancient Potion, which are now Uncommon.
  • Weekly Patch 16: Back to Work
    • Relics and Potions in the shop now correctly set their prices when restocked with TheCourier.png the Courier.
  • Weekly Patch 13: Thinking Ahead
    • Sozu.png Sozu now prevents you from acquiring new potions rather than preventing usage (similar to Ectoplasm.png Ectoplasm).
    • Fixed bug where Nemesis could take more than 1 damage from Icon Thorns.png Thorns, Potions, and relics like LetterOpener.png Letter Opener.
  • Weekly Patch 11: A Library of Features
    • If you attempt to get a deprecated potion, you now get a FirePotion.png Fire Potion.
  • Weekly Patch 10: Quality of Life
    • Adding new AncientPotion.png Ancient Potion.
    • Removed Elixir Potion from the game.
  • Weekly Patch 6: We're Back!
    • Elixir potion buff: Now also affects .
  • Weekly Patch 5: Happy Holidays!
    • New Potion, Elixir.
    • Potions now save using their ID rather than their NAME (wasn't loading in other languages).
    • You can no longer open the potions dropdown if you're holding a card.
  • Weekly Patch 4: Full speed ahead!
    • Added a period at the end of RegenPotion.png Regen Potion's description.
  • Weekly Patch 2: Slimes!
    • DexterityPotion.png Dexterity Potion description updated for clarity/consistency.
    • StrengthPotion.png Strength Potion description updated for clarity/consistency.