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Potions are one-time-use items that can only be used in combat(with the exception of Fruit Juice, which can be used in most scenarios). The player can typically hold up to 3 of them at any given time, or 5 with the Potion Belt relic. However, on ascension levels 11 and higher, the player only has 2 potion slots, or 4 with the Potion Belt.

Using a potion does not require Energy.

Potions are occasionally dropped as a reward after combat. They can also be bought at Merchants or obtained from some Events. Neow also offers 3 random potions as a starting blessing.

Icon Name Rarity Effect
AncientPotion
Ancient Potion Uncommon Gain 1 Artifact.
AttackPotion
Attack Potion Common Add 1 of 3 random Attack cards to your hand, it costs 0 this turn.
BlockPotion
Block Potion Common Gain 12 Block.
BloodPotion
Blood Potion (Ironclad only) Uncommon Heal for 10% of your Max HP.
DexterityPotion
Dexterity Potion Common Gain 2 Dexterity.
EnergyPotion
Energy Potion Common Gain 2 Energy.
EntropicBrew
Entropic Brew Rare Fill all your empty potion slots with random potions.
EssenceOfSteel
Essence of Steel Uncommon Gain 4 Plated Armor.
ExplosivePotion
Explosive Potion Common Deal 10 Damage to all enemies.
FairyinaBottle
Fairy in a Bottle Rare When you would die, heal to 10% of your Max HP instead and discard this potion.
FearPotion
Fear Potion Common Apply 3 Vulnerable.
FirePotion
Fire Potion Common Deal 20 Damage to target enemy.
FocusPotion
Focus Potion

(Defect only)

Uncommon Gain 2 Focus.
FruitJuice
Fruit Juice Rare Gain 5 Max HP.
GamblersBrew
Gambler's Brew Uncommon Discard any number of cards, then draw that many.
GhostInAJar
Ghost In A Jar (Silent only) Uncommon Gain 1 Intangible.
LiquidBronze
Liquid Bronze Uncommon Gain 3 Thorns.
PoisonPotion
Poison Potion Common Apply 6 Poison to target enemy.
PowerPotion
Power Potion Common Add 1 of 3 random Power cards to your hand, it costs 0 this turn.
RegenPotion
Regen Potion Uncommon Gain 5 Regeneration.
SkillPotion
Skill Potion Common Add 1 of 3 random Skill cards to your hand, it costs 0 this turn.
SmokeBomb
Smoke Bomb Rare Escape from a non-boss combat. Receive no rewards.
SneckoOil
Snecko Oil Rare Become Confused. Draw 3 Cards.
SpeedPotion
Speed Potion Common Gain 5 Dexterity. At the end of your turn, lose 5 Dexterity.
SteroidPotion
Steroid Potion Common Gain 5 Strength. At the end of your turn, lose 5 Strength.
StrengthPotion
Strength Potion Common Gain 2 Strength.
SwiftPotion
Swift Potion Common Draw 3 cards.
WeakPotion
Weak Potion Common Apply 3 Weak to target enemy.