Orange Pellets is a relic that can only be found in the shop that removes all your debuffs if you play a Power, Attack, and skill in the same turn.
Note that this relic can remove the debuffs inflicted on yourself via certain cards, such as Biased Cognition and Wraith Form; this can make such cards far more valuable. Flex also works via a debuff and will provide strength for the rest of the combat if it can be removed that turn. The same goes for Speed and Flex potion.
Related to the above, the Confused debuff that is inflicted by the Snecko Eye relic will be removed. Any cards that were previously drawn will retain their current costs for the rest of combat. The bonus card draw effect will also remain active.
Negative stat debuffs, such as negative Strength, Dexterity and Focus can be removed by this artifact, however it cannot always undo their loss. If you lose some Strength but still have a positive amount of Strength, Orange Pellets will not be able to reverse its loss; it can only bring you back to neutral.
If the last card played to activate this relic applies a debuff, that debuff will be removed. Debuffs from a second play (such as those enabled by the Necronomicon), however, will remain.