The Nemesis's Intangible buff is applied just before attacking at the end of the first turn, making it reduce all incoming damage (including Poison and Thorns) to 1. This buff will only last for 1 turn (ending after attacking the following turn), but will reapply every other turn, giving the fight a clear tempo of attack and defend. Players should generally avoid attacking while Intangible is up, but applying Poison or using power cards is recommended.
Nemesis' attacks do not increase in power through the fight, but without a source of Exhaust the player will eventually be overwhelmed with Burn cards, so they should take care not to let the fight last too long.
The Boot ignores Intangible's damage reduction, so all unblocked attack damage dealt will be increased to 5. This is not run-changing, but serves some use in this fight.
The Pagan imagery of both the Silent and Nemesis hint at ritualistic conflict. Wearing similar ornaments, the Nemesis is revered by the Silent's tribe in some way, possibly a fallen predecessor or mythical enemy.