Necronomicon is a Relic obtained through the Cursed Tome Event.
Picking up this relic will give the player a "Necronomicurse", an unplayable Card that cannot be removed from your deck by any means.
The Necronomicurse counts for Du-Vu Doll.
Interestingly, the Omamori will in fact negate the Necronomicurse entirely.
Trivia 
Edit
- This relic is a reference to the Necronomicon from Spelunky, which references the Evil Dead franchise, which in turn references the Necronomicon from the writings of H.P. Lovecraft, in which it is an evil tome containing otherworldly secrets that will drive humans to insanity merely from learning them.
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