Meteor Strike is an Attack card for The Defect that deals a huge amount of damage, channels a lot of Plasma Orbs, and has a notoriously restrictive Energy cost.
Upgrading Meteor Strike increases its damage from 24 to 30.
Meteor Strike requires The Defect to generate two extra Energy just to play it! The payoff is worth the effort - big damage, three Evokes, and six Energy to play with the following turn.
Taking Meteor Strike without high-powered Energy generation is extremely risky. Instead, gather up Fusion, Aggregate, Double Energy, and Energy-generating Boss Relics like Cursed Key and then find the Meteor Strike.
Since Meteor Strike provides no defense, expect to take some damage the first time it's played. Subsequent plays will actually generate Energy, since remaining Plasma Orbs will probably be Evoked.
Plasma Orbs consistently generate Energy turn after turn, so Meteor Strike stabilizes a single-turn Energy boost like Double Energy into an Energy advantage that can last through the rest of the game.
Meteor Strike obviously requires Energy generation. Relics are best, but in practice, a combination of Relics and Skills will probably be necessary. TURBO is actually a good choice, as the Plasma Orbs offset Void's Energy loss.
Playing Meteor Strike with an active Echo Form is frankly ridiculous.
One of Meteor Strike's strongest synergies is Tempest. Tempest Evokes the Plasma orbs, enabling a 12-Energy turn. Meteor Strike then Evokes the Lightning Orbs, dealing 45 total damage and restoring the Plasma.
Snecko Eye can reduce Meteor Strike's cost enough to play without Energy generation. Snecko Eye will also never raise its cost, making the combo pure upside.