When you would die, heal to 50% of your Max HP instead (works once).
Be aware that if the enemy has an attack that hits multiple times, the first hit can kill you and subsequent hits can kill you again, although the damage left over from the killing hit does not carry over after you get healed up.
If the player also has Fairy in a Bottle, it triggers first, and Lizard Tail will not activate until you reach 0 HP again.
Since Lizard Tail's effect heals you, Mark of the Bloom will prevent it from working.
Update History[]
Patch V2.0: The Watcher
Lizard Tail relic rarity changed from Boss -> Rare.
Weekly Patch 51: Recursion
Muzzle blight was applying twice to Lizard Tail and Fairy Potion.
Weekly Patch 32: Face Trader
Fixed Fairy Potion and Lizard Tail not triggering with Muzzle blight.