- When combined with Sadistic Nature, envenom will trigger the additional damage on every hit you make, which can be extremely effective with any sort of shiv or multi-hit strategy.
- Snecko Skull will effectively double the Poison inflicted by this card (and produce even more damage than that in the long term); in concert with a large number of attacks, this is one of the most effective ways to use that relic.
- Envenom is extremely effective at removing stacks of Artifact, since each hit counts as a separate debuff and expends an instance of Artifact to prevent it.
- Patch V1.1: The Dealer
- Envenom's Poison is now applied immediately after the damage occurs.
- Weekly Patch 42: Reboot
- Updating icon for Envenom power.
- Weekly Patch 5: Happy Holidays!
- Envenom card gets a wording update for clarity.
- Updating description for Envenom power to mention unblocked dmg.