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A debuff is a negative ongoing effect given to the character or an enemy by certain Cards, Relics, or Potions.

Debuffs can be negated by the Icon Artifact Artifact Buff.

Debuffs may stack by duration, lasting X turns, or by intensity, applying their effect with X power. Some debuffs do not stack at all.

Icon Name Sources Effects Stacks?
Icon Bias Bias Biased Cognition At the start of your turn, lose X Icon Focus Focus. Intensity
Icon Choke Choke Choke Whenever you play a card this turn, the targeted enemy loses X HP. Intensity
Icon Confused Confused Snecko, Snecko Eye The costs of your cards are randomized on draw, from 0 to 3. No
Icon Restricted Constricted Spire Growth At the end of your turn, take X damage. Intensity
Icon CorpseExplosion Corpse Explosion Corpse Explosion On death, the enemy deals X times its Max HP worth of damage to all other enemies. Intensity
Dexterity Dexterity (Negative) Lagavulin, Bear, Wraith Form (indirectly) Decreases Icon Block Block gained from cards by X. Intensity
Icon StrengthDown Dexterity Down Duality, Speed Potions At the end of your turn, lose X Icon Dexterity Dexterity. Intensity
Icon DrawReduction Draw Reduction Time Eater Draw 1 less card next X turns. Duration
Icon Entangled Entangled Red Slaver You may not play any Attacks this turn. No
Icon Fasting Fasting Fasting Gain X less Energy at the start of each turn. Intensity
Icon Focus Focus (Negative) Biased Cognition (Indirectly), Hyperbeam, Spire Shield Decreases the effectiveness of your Orbs by X. Intensity
Icon Frail Frail Various enemies, Shame. Icon Block Block gained from cards is reduced by 25%. Duration
Icon Hex Hex Chosen Whenever you play a non-Attack card, add X Dazed to your draw pile. Intensity
Icon Mark Mark Pressure Points Whenever you play Pressure Points, the targeted enemy loses X HP. Intensity
Icon NoDraw No Draw Bullet Time, Battle Trance You may not draw any more cards this turn. No
Icon NoGuard No Block Panic Button You may not gain Icon Block Block from cards for the next X turns. Duration
Icon Poison Poison Various Silent cards, Poison Potion. At the beginning of its turn, the target loses X HP and 1 stack of poison. Intensity and Duration
Icon Shackled Shackled Piercing Wail, Dark Shackles, Transient At the end of its turn, regains X Icon Strength Strength. Intensity
Icon Slow Slow Giant Head Whenever you play a card, the enemy receives 10% more damage from attacks this turn. Intensity
Icon Strength Strength (Negative) Lagavulin, Malaise, Disarm, Piercing Wail, Dark Shackles Decreases attack damage by X. Intensity
Icon StrengthDown Strength Down Flex Potions, Flex At the end of your turn, lose X Icon Strength Strength. Intensity
Icon TalktotheHand Talk to the Hand Talk to the Hand Whenever you attack this enemy, gain X Icon Block Block. Intensity
Icon Vulnerable Vulnerable Various enemies, Berserk, various cards, Fear Potion Target takes 50% more damage from attacks. Duration
Icon Weak Weak Various enemies, Doubt, Gremlin Visage, various cards, Weak Potion Target deals 25% less attack damage. Duration
Icon WraithForm Wraith Form Wraith Form Lose X Icon Dexterity Dexterity at the start of your turn. Intensity
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