A debuff is a negative ongoing effect given to the character or an enemy by certain Cards, Relics, or Potions.
Debuffs can be negated by the Artifact Buff.
Debuffs may stack by duration, lasting X turns, or by intensity, applying their effect with X power. Some debuffs do not stack at all.
| Icon | Name | Sources | Effects | Stacks? |
|---|---|---|---|---|
| Bias | Biased Cognition | At the start of your turn, lose X Focus. | Intensity | |
| Choke | Choke | Whenever you play a card this turn, the targeted enemy loses X HP. | Intensity | |
| Confused | Snecko, Snecko Eye, Snecko Oil Potion | The costs of your cards are randomized on draw, from 0 to 3. | No | |
| Constricted | Spire Growth | At the end of your turn, take X damage. | Intensity | |
| Corpse Explosion | Corpse Explosion | On death, the enemy deals X times its Max HP worth of damage to all other enemies. | Intensity | |
| Dexterity(negative) | Lagavulin, Bear, Wraith Form(indirectly) | Decreases Block gained from cards by X. | Intensity | |
| Dexterity Down | Speed Potions | At the end of your turn, lose X Dexterity. | Intensity | |
| Draw Reduction | Time Eater | Draw 1 less card next turn. | Duration | |
| Entangled | Red Slaver | You may not play any Attacks this turn. | No | |
| Focus(negative) | Biased Cognition(indirectly), Hyperbeam, Spire Shield | Decreases the effectiveness of your Orbs by X. | Intensity | |
| Frail | Various enemies, Shame. | Block gained from cards is reduced by 25%. | Duration | |
| Hex | Chosen | Whenever you play a non-Attack card, add X Dazed to your draw pile. | Intensity | |
| No Draw | Bullet Time, Battle Trance | You may not draw any more cards this turn. | No | |
| No Block | Panic Button | You may not gain Block from cards for the next X turns. | Duration | |
| Poison | Various Silent cards, Poison Potion. | At the beginning of its turn, the target loses X HP and 1 stack of poison. | Intensity | |
| Shackled | Piercing Wail, Dark Shackles, Transient | At the end of its turn, regains X Strength. | Intensity | |
| Slow | Giant Head | Whenever you play a card, the enemy receives 10% more damage from attacks this turn. | Intensity | |
| Strength(negative) | Lagavulin, Malaise, Disarm, Piercing Wail, Dark Shackles | Decreases attack damage by X. | Intensity | |
| Strength Down | Steroid Potions, Flex | At the end of your turn, lose X Strength. | Intensity | |
| Vulnerable | Various enemies, Berserk, various cards, Fear Potion | Target takes 50% more damage from attacks. | Duration | |
| Weak | Various enemies, Doubt, Gremlin Visage, various cards, Weak Potion | Target deals 25% less attack damage. | Duration | |
| Wraith Form | Wraith Form | Lose X Dexterity at the start of your turn. | Intensity |