Debuffs may stack by duration, lasting X turns, or by intensity, applying their effect with X power. Some debuffs do not stack at all.
Debuffs that can be found from multiple sources in the game, both in the player's arsenal and from enemies.
|Confused||The costs of your cards are randomized on draw, from 0 to 3.||No|
|Dexterity (Negative)||Decreases Block gained from cards by X.||Intensity|
|Dexterity Down||At the end of your turn, lose X Dexterity.||Intensity|
|Focus (Negative)||Decreases the effectiveness of your Orbs by X.||Intensity|
|Frail||Block gained from cards is reduced by 25%.||Duration|
|No Draw||You may not draw any more cards this turn.||No|
|Poison||At the beginning of its turn, the target loses X HP and 1 stack of Poison.||Intensity and Duration|
|Shackled||At the end of its turn, regains X Strength.||Intensity|
|Slow||The enemy receives (X*10)% more damage from attacks this turn. Whenever you play a card, increases X by 1.||Intensity|
|Strength (Negative)||Decreases attack damage by X.||Intensity|
|Strength Down||At the end of your turn, lose X Strength.||Intensity|
|Vulnerable||Target takes 50% more damage from attacks.||Duration|
|Weak||Target deals 25% less attack damage.||Duration|
Debuffs that comes from a single source.
|Bias||Player||Biased Cognition||At the start of your turn, lose X Focus.||Intensity|
|Block Return||Enemy||Talk to the Hand||Whenever you attack this enemy, gain X Block.||Intensity|
|Choked||Enemy||Choke||Whenever you play a card this turn, the targeted enemy loses X HP.||Intensity|
|Constricted||Player||Spire Growth||At the end of your turn, take X damage.||Intensity|
|Corpse Explosion||Enemy||Corpse Explosion||On death, the enemy deals X times its Max HP worth of damage to all other enemies.||Intensity|
|Draw Reduction||Player||Time Eater||Draw 1 less card next X turns.||Duration|
|Entangled||Player||Red Slaver||You may not play any Attacks this turn.||No|
|Fasting||Player||Fasting||Gain X less Energy at the start of each turn.||Intensity|
|Hex||Player||Chosen||Whenever you play a non-Attack card, add X Dazed to your draw pile.||Intensity|
|Lock-On||Enemy||Bullseye||Lightning and Dark orbs deal 50% more damage (rounded down) to the targeted enemy.||Duration|
|Mark||Enemy||Pressure Points||Whenever you play
Pressure Points, all enemy with Mark loses X HP.
|No Block||Player||Panic Button||You may not gain Block from cards for the next X turns.||Duration|
|Wraith Form||Player||Wraith Form||Lose X Dexterity at the start of your turn.||Intensity|