Curses are negative cards that stay in your deck. Under normal circumstances, all curses are unplayable, and many impose an additional negative effect. When you have a Blue Candle you can play Curses, which will make you lose 1 HP and exhausts the card.
| Name | Picture | Description | Notes |
|---|---|---|---|
| Ascender's Bane |  | Unplayable.
Cannot be removed from your deck. Ethereal. | (Obtained from Ascension level 10 and higher at the start of the game.) |
| Clumsy |  | Unplayable. | |
| Curse of the Bell (BETA) | N/A | Unplayable. Cannot be removed from your deck. | (Obtained from Calling Bell when acquired.) |
| Decay |  | Unplayable.
At the end of your turn, take 2 damage. | |
| Doubt |  | Unplayable.
At the end of your turn, gain 1 Weak. | |
| Injury |  | Unplayable. | |
| Necronomicurse |  | Unplayable.
There is no escape from this Curse. (Cannot be Exhausted or Removed from your deck.) | (Obtained from event: Cursed Tome's Necronomicon reward) |
| Normality |  | Unplayable.
You cannot play more than 3 cards this turn. | |
| Pain |  | Unplayable.
While in hand, lose 1 HP when other cards are played. | |
| Parasite |  | Unplayable.
If transformed or removed from your deck, lose 3 Max HP. | |
| Pride |  | Innate.
At the end of your turn, put a copy of this card on top of your draw pile. Exhaust. | (Obtained from the Grotesque Trophy Blight in Endless Mode.) |
| Regret |  | Unplayable.
At the end of your turn, lose HP equal to the number of cards in your hand. | |
| Shame |  | Unplayable.
At the end of your turn, gain 1 Frail. | |
| Writhe |  | Unplayable. |
