Curses are negative cards. Unlike Status cards, they stay in your deck outside of combat. Under normal circumstances, all curses are unplayable, and many impose an additional negative effect. 
Blue Candle lets you play Curses, which will make you lose 1 HP and Exhausts the card.
Curses can only Transform into other curses. When an effect (such as 
Cursed Key or Transform) generates a random curse, it can only become one of the following:
The above curses and Pride are the only ones that can be removed from the deck.
| Name | Picture | Description | Notes |
|---|---|---|---|
| Ascender's Bane |  |
Unplayable.
Cannot be removed from your deck. Ethereal. |
(Obtained from Ascension level 10 and higher at the start of the game.) |
| Clumsy |   |
Unplayable. | |
| Curse of the Bell |   |
Unplayable. Cannot be removed from your deck. | (Obtained from Calling Bell when acquired.) |
| Decay |   |
Unplayable.
At the end of your turn, take 2 damage. |
|
| Doubt |   |
Unplayable.
At the end of your turn, gain 1 |
|
| Injury |   |
Unplayable. | |
| Necronomicurse |   |
Unplayable.
There is no escape from this Curse. (Cannot be Removed from your deck. When Exhausted, a new copy appears in your hand.) |
(Obtained when  Necronomicon is acquired. Removed if Necronomicon is disacquired.)
|
| Normality |   |
Unplayable.
You cannot play more than 3 cards this turn. |
|
| Pain |   |
Unplayable.
While in hand, lose 1 HP when other cards are played. |
|
| Parasite |   |
Unplayable.
If transformed or removed from your deck, lose 3 Max HP. |
|
| Pride |   |
Innate.
At the end of your turn, put a copy of this card on top of your draw pile. Exhaust. |
(Obtained from the Grotesque Trophy Blight in Endless Mode.) |
| Regret |   |
Unplayable.
At the end of your turn, lose HP equal to the number of cards in your hand. |
|
| Shame |   |
Unplayable.
At the end of your turn, gain 1 |
|
| Writhe |   |
Unplayable. |
