A buff is a positive effect given to the character by certain Cards, Potions, or Relics. Buffs can also be applied to enemies through their moves or certain Relics, or they can simply start combat with the buff. All buffs are removed at the end of combat and do not carry over to the next fight. Certain relics (for example, Girya) apply buffs at the start of combat.
Buffs may stack by duration, lasting X turns, or by intensity, applying their effect with X power. Some buffs do not stack at all. However, most stack by intensity.
Buffs that can be found from multiple sources in the game, both in the player's arsenal and on enemies.
|Artifact||Negates X debuffs.||Counter|
|Barricade||Block is not removed at the start of turn.||No|
|Buffer||Prevent the next X times you would lose HP.||Counter|
|Dexterity||Increases Block gained from cards by X.||Intensity|
|Draw Card||Draw X additional cards next turn.||Intensity|
|Energized||Gain X additional Energy next turn.||Intensity|
|Focus||Increases the effectiveness of Orbs by X.||Intensity|
|Intangible||Reduce ALL damage taken and HP loss to 1 this turn. (lasts X turns)||Duration|
|Mantra||When you gain 10 Mantra, enter Divinity||Counter|
|Metallicize||At the end of your/its turn, gain X Block.||Intensity|
|Next Turn Block||Gain X Block next turn.||Intensity|
|Plated Armor||At the end of your turn, gain X Block. Receiving unblocked attack damage reduces Plated Armor by 1.||Intensity|
|Regen||At the end of its turn, heals X HP.||Intensity|
|Ritual||At the end of its turn, gains X Strength.||Intensity|
|Strength||Increases attack damage by X.||Intensity|
|Thorns||When attacked, deals X damage back.||Intensity|
|Vigor||Your next Attack deals X additional damage.||Intensity|
Buffs granted to the player that comes from a single source, usually a Power cards, but not always. Their source are usually the card of the same name, unless stated otherwise.
|Accuracy||Shivs deal X additional damage.||Intensity|
|After Image||Whenever you play a card, gain X Block||Intensity|
|Amplify||Your next X Power cards are played twice.||Counter|
|Battle Hymn||At the start of each turn add X Smites into your hand.||Intensity|
|Berserk||At the start of your turn, gain X Energy.||Intensity|
|Blasphemer||Blasphemy||At the start of your turn, die. ||No|
|Blur||Block is not removed at the start of your next X turns.||Duration|
|Brutality||At the start of your turn, lose X HP and draw X cards.||Intensity|
|Burst||Your next X Skills are played twice.||Counter|
|Collect||Put an Upgraded Miracle into your hand at the start of your next X turns.||Duration|
|Combust||At the end of your turn, lose 1 HP(for each Combust played) and deal X damage to ALL enemies.||Intensity|
|Corruption||Skills cost 0. Whenever you play a Skill, Exhaust it.||No|
|Creative AI||At the start of your turn, add X random Power cards into your hand.||Intensity|
|Dark Embrace||Whenever a card is Exhausted, draw X cards.||Intensity|
|Demon Form||At the start of your turn, gain X Strength.||Intensity|
|Deva||Deva Form||At the start of your turn gain Energy N times and increase this gain by X.||Intensity|
|Devotion||At the start of your turn, gain X Mantra.||Intensity|
|Double Damage||Phantasmal Killer||Attacks deal double damage for X turns.||Duration|
|Double Tap||Your next X Attacks are played twice.||Counter|
|Duplication||Duplication Potion||Your next X cards are played twice.||Counter|
|Echo Form||The first X cards you play each turn are played twice.||Counter|
|Electro||Electrodynamics||Lightning hits ALL enemies.||No|
|Envenom||Whenever you deal unblocked attack damage, apply X Poison||Intensity|
|Equilibrium||Retain your hand for X turns.||Duration|
|Establishment||Whenever a card is Retained, lower its cost by X.||Intensity|
|Evolve||Whenever you draw a Status, draw X cards.||Intensity|
|Feel No Pain||Whenever a card is exhausted, gain X Block||Intensity|
|Fire Breathing||Whenever you draw a Status or Curse card, deal X damage to ALL enemies.||Intensity|
|Flame Barrier||When attacked, deals X damage back. Wears off at the start of your next turn.||Intensity|
|Foresight||At the start of your turn, Scry X.||Intensity|
|Free Attack Power||Swivel||The next X Attacks you play costs 0.||Counter|
|Heatsink||Heatsinks||Whenever you play a Power card, draw X cards.||Intensity|
|Hello||Hello World||At the start of your turn, add X random Common cards into your hand.||Intensity|
|Infinite Blades||At the start of your turn, add X Shivs into your hand.||Intensity|
|Juggernaut||Whenever you gain Block, deal X damage to a random enemy.||Intensity|
|Like Water||At the end of your turn, if you are in Calm, gain X Block.||Intensity|
|Loop||At the start of your turn, trigger the passive ability of your next Orb X times.||Intensity|
|Machine Learning||At the start of your turn, draw X additional cards.||Intensity|
|Magnetism||At the start of your turn, add X random colorless cards into your hand.||Intensity|
|Master Reality||Whenever a card is created during combat, Upgrade it.||No|
|Mayhem||At the start of your turn, play the top X card of your draw pile.||Intensity|
|Mental Fortress||Whenever you switch Stances, gain X Block.||Intensity|
|Nightmare||Add X of a chosen card into your hand next turn.||Special|
|Nirvana||Whenever you Scry, gain X Block.||Intensity|
|Noxious Fumes||At the start of your turn, apply X Poison to ALL enemies.||Intensity|
|Omega||At the end of your turn, deal X damage to ALL enemies.||Intensity|
|Panache||If you play N more cards this turn, deal X damage to all enemies.||Intensity|
|Pen Nib||Your next Attack deals double damage.||No|
|Phantasmal||Phantasmal Killer||Deal Double Damage for the next X turns.||Duration|
|Rage||Whenever you play an Attack, gain X Block.||Intensity|
|Rebound||The next X cards you play this turn are placed on top of your draw pile.||Counter|
|Regen||At the end of your turn, heal X HP and reduce Regen by 1.||Intensity and Duration|
|Rushdown||Whenever you enter Wrath, draw X cards.||Intensity|
|Repair||Self Repair||At the end of combat, heal X HP.||Intensity|
|Rupture||Whenever you lose HP from a card, gain X Strength.||Intensity|
|Sadistic||Sadistic Nature||Whenever you apply a debuff to an enemy, deal X damage.||Intensity|
|Simmering Rage||Simmering Fury||At the start of your next turn, enter Wrath||No|
|Static Discharge||Whenever you receive attack damage, channel X Lightning.||Intensity|
|Storm||Whenever you play a Power card, channel X Lightning.||Intensity|
|Study||At the end of your turn, shuffle X Insights into your draw pile.||Intensity|
|Surrounded||Spire Shield and Spire Spear||Receive 50% more damage if attacked from behind. Use targeting cards or potions to change your orientation.||No|
|The Bomb||At the end of N turns, deal X damage to all enemies.||Special|
|Thousand Cuts||A Thousand Cuts||Whenever you play a card, deal X damage to ALL enemies.||Intensity|
|Tools of the Trade||At the start of your turn, draw X cards and discard X cards.||Intensity|
|Wave of the Hand||Whenever you gain Block this turn, apply X Weak to ALL enemies.||Intensity|
|Well-Laid Plans||At the end of your turn, Retain up to X cards.||Intensity|
These buffs are exclusive to enemies, and cannot be obtained by the player.
|Angry||Mad Gremlin||Upon receiving attack damage, gains X Strength.||Intensity|
|Back Attack||Spire Shield and Spire Spear||Deals 50% more damage as it is attacking you from behind.||No|
|Beat of Death||Corrupt Heart||Whenever you play a card, take X damage.||Intensity|
|Curiosity||Awakened One||Whenever you play a Power card, gains X Strength.||Intensity|
|Curl Up||Louses||On receiving attack damage, rolls up and gains X Block (Once per combat).||Intensity|
|Enrage||Gremlin Nob||Whenever you play a skill, gains X Strength||Intensity|
|Explosive||Exploder||Explodes in N turns, dealing X damage.||Special|
|Fading||Transient||Dies in X turns.||Duration|
|Invincible||Corrupt Heart||Can only lose X more HP this turn.||Intensity|
|Life Link||Darkling||If other Darklings are still alive, revives in 2 turns.||No|
|Malleable||Snake Plant, Writhing Mass||Upon receiving attack damage, gains X Block. Block gain increases as Malleable is triggered. Resets to X at the start of your turn.||Intensity|
|Minion||Gremlin Leader's Gremlins, Bronze Automaton's Bronze Orbs, The Collector's Torch Heads, Reptomancer's Daggers||Minions abandon combat without their leader.||No|
|Mode Shift||The Guardian||After receiving X damage, changes to a defensive mode.||Intensity|
|Painful Stabs||Corrupt Heart, Book of Stabbing||Whenever you receive attack damage from this enemy, add X Wounds into your discard pile.||Intensity|
|Reactive||Writhing Mass||Upon receiving attack damage, changes its intent.||No|
|Sharp Hide||The Guardian||Whenever you play an attack, take X damage.||Intensity|
|Shifting||Transient||Upon losing HP, loses that much Strength until the end of the turn.||No|
|Split||Acid Slime, Spike Slime, Slime Boss||When its HP is at or below 50%, will split into 2 smaller Slimes with its current HP.||No|
|Spore Cloud||Fungi Beast||On death, applies X Vulnerable||Intensity|
|Stasis||Bronze Orbs||On death, a stolen card is returned to your hand.||No|
|Strength Up||Orb Walker||At the end of its turn, gains X Strength.||Intensity|
|Thievery||Thieves||Steals X Gold whenever it attacks.||Intensity|
|Time Warp||Time Eater||Whenever you play N cards, ends your turn and gains X Strength.||Counter|
|Unawakened||Awakened One||This enemy hasn't awakened yet...||No|
- Despite its description, Blasphemer actually causes you to receive an amount of damage so large that you will die, which can be prevented by Buffer and Intangible.
- N of Deva starts at 1, and X is 1 by default. The turn after it is applied, you will gain Energy N times, and then X is added to N every turn after. Each further application add 1 to both N and X.
- Its buff counter also only identify X, or a number of time this card is applied to be exact. It does not have an identification for a total N of each turn.
- The Bomb and Nightmare create separate buffs for each card use rather than stacking normally.
- N of Panache is 5 by default and decreases by 1 whenever you play a card. Once it reaches 0, it deals damage and roll back to 5 again.
- Using multiple Panache only increases its damage. Its N, or card countdown, is always 5.
- N of The Bomb is 3 by default and decreases by 1 at the end of your turn. Once it reaches 0, it deals damage and expires.
- N of Explosive starts at 3 and decreases by 1 at the end of its turn. Once it reaches 0, Exploder deals 30 damage and expires. Its intent will change to identify that it is about to explode.
- N of Fading starts at 5 (6 from Ascension 17 onward) and decreases by 1 at the end of its turn. Transient immediately dies once Fading reaches 0.
- Life Link effectively prevents Darkling from being dead until all the other Darkling are killed. Its intent will change to signify its revive. Fatal does not work unless it kills the last Darkling. Card or relic that simply works on enemy kill and does not have Fatal, such as Sunder and Gremlin Horn, still works after you killed an individual Darkling.
- Cultists in Awakened One boss fight also abandon combat when the boss is killed in its second phase, even though they do not have Minion buff.
- Time Warp starts at 0 and increases by 1 after you played a card. By default, once it reaches 12 you will immediately end your turn as the effect of 12th card resolves and Time Eater will gain Strength.
- The number on Time Warp buff is only a counter of the number of cards the player has played, and does not indicate the potency of the buff.