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Blights are detrimental passive items, like a negative version of relics. They appear in Endless Mode. They are forced onto the player by Neow each time they defeat Act 3 bosses, and from blight chests, if the Blight Chests mod is on.

Neow's Blights

Each time the player defeats the Act 3 boss and loops back to Act 1, they obtain a set of blights from Neow. The following is a list of blights that can be obtained from Neow.

Image Title Description
Grotesque Trophy Upon pickup, obtain 3 Prides.
Mimic Infestation Treasure rooms in future acts are replaced by Elites. Elites no longer drop Relics.
Muzzle You can no longer increase your Max HP. All healing is halved.
Spear of Blight Enemies deal 100% more damage.
Shield of Blight Enemies have 50% more HP.
Time Maze.PNG
Time Maze You cannot play more than 15 cards per turn.[1]

[1] Curses do not count towards Time Maze's 15-card limit.


The set of blights that player obtains from Neow is in the following order.

1st set

  • Spear of Blight starts at a 100% increase
  • Shield of Blight starts at a 50% increase
  • Mimic Infestation

2nd set

  • Spear of Blight increases from 100% to 175%
  • Shield of Blight increases from 50% to 100%
  • Time Maze

3rd set

  • Spear of Blight increases from 175% to 250%
  • Shield of Blight increases from 100% to 150%
  • Muzzle

4th set and afterwards

  • Spear of Blight increases by 75% each set
  • Shield of Blight increases by 50% each set
  • Grotesque Trophy each set

Blight Chests

With Blight Chests mod turned on, each boss chest from the 4th chest onward is replaced by a Blight Chest, where the player is forced to choose 1 from 2 random Blights to obtain (cannot skip). The following is a list of blights that can be obtained from Blight Chests. All Blights from Blight Chests stack its effect if more than 1 copy is obtained, like Spear and Shield blights.

Image Title Description
Accursed Whenever you defeat a Boss, obtain 2 random Curses.
Ancient Augmentation Enemies start combat with 1 Icon Artifact.png Artifact, 10 Icon PlatedArmor.png Plated Armor, and 10 Icon Regen.png Regenerate.
Durian Lose 50% of your Max HP.
Hauntings Enemies start combat with 1 Icon Intangible.png Intangible.
Scatterbrain Draw 1 less card a turn.
Twisting Mind At the end of your turn, add 1 random Status card to the top of your draw pile.
Void essence.png
Void Essence Lose 1 Energy permanently.

Update History

  • Weekly Patch 54: Loop
    • Blight rolling now increments relic rng seeds correctly (consistency on save/load)
  • Weekly Patch 51: Recursion
    • Muzzle blight was applying twice to Lizard Tail and Fairy Potion.
  • Weekly Patch 40: Forethought
    • Shifting Power (Transient) should now interact correctly, even if the owner has Artifact.
  • Weekly Patch 36: Power Through
    • Improved blight stacking for Endless. Grotesque Trophy is just 1 blight now.
  • Weekly Patch 33: Terror
    • Endless mod added to Custom Mode. Enemies get stronger and stronger.
    • Blight Chests mod added to Custom Mode. Boss chests give unique unavoidable blights for added challenge.
  • Weekly Patch 32: Face Trader
    • Fixed Fairy Potion and Lizard Tail not triggering with Muzzle blight.
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