Slay the Spire Wiki
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Ascension is an experimental game mode that basically adds new challenge runs for added difficulty.

In order to unlock Ascension 1, you must have beaten all 3 of the Act 3 Bosses on this save file.

Winning a run in each Ascension will unlock the next Ascension for that character only.

Losing a run will NOT reset any progress or decrease your Ascension number.

You may only play the highest Ascension level you have unlocked; you cannot go back to a lower level.

Modifiers

  1. Elites spawn more often.
  2. Normal enemies are deadlier.
  3. Elites are deadlier.
  4. Bosses are deadlier.
  5. Heal less after Boss battles.
  6. Start each run damaged.
  7. Normal enemies are tougher.
  8. Elites are tougher.
  9. Bosses are tougher.
  10. Parasite!
  11. Potions are less potent.
  12. Upgraded cards appear less often.
  13. Bosses drop less gold.
  14. Lower max HP.
  15. Unfavorable events.
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