Slay the Spire Wiki
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Artifact is a buff that will negate the next debuff on that unit.

Each stack of Artifact can block 1 application of: Weak, Vulnerable, Poison, Frail, Strength Loss, etc.

  • Bouncing Flask will remove 1 Artifact with each bounce.
  • Envenom will remove 1 Artifact with each unblocked Attack.
  • Shockwave will remove up to 2 Artifacts from each enemy.

The player can gain Artifact through the Colorless card, Panacea.

Enemies with Artifact:

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