Slay the Spire Wiki

Icon Artifact.png Artifact is a buff that will negate the next Debuff on that unit.

Each stack of Icon Artifact.png Artifact can block 1 application of a Debuff. For example:

  • Bouncing Flask will remove 1 Icon Artifact.png Artifact with each bounce.
  • Envenom will remove 1 Icon Artifact.png Artifact with each unblocked Attack damage.
  • Shockwave and Crippling Cloud will remove up to 2 Icon Artifact.png Artifacts from each enemy, since they inflicts 2 Debuffs.

Effects that apply multiple Debuffs will do so in the order listed on the card. For instance, if an enemy has 1 Icon Artifact.png Artifact and is hit by Shockwave, the card will apply Icon Weak.png Weak then apply Icon Vulnerable.png Vulnerable as per its description, and the enemy will lose 1 Icon Artifact.png Artifact to negate Icon Weak.png Weak and only has Icon Vulnerable.png Vulnerable inflicted on it.

Enemy Interactions[]

  • Note that all cards that inflict ongoing effects on enemies work via their own special Debuff even if it's not specifically identified on the card; these will still be negated by Icon Artifact.png Artifact. For instance, the ongoing effects of Corpse Explosion or Choke can be negated by Icon Artifact.png Artifact.
  • Enemy attacks which immediately add a card, whether Status or Curse to your deck, such as the Slime Boss' Debuff1.png Goop Spray, the Taskmaster's Attack-debuff-common.png Scouring Whip, or Writhing Mass' Debuff2.png Implant, are depicted as inflicting negative effects and might give the impression it can be negated by an Icon Artifact.png Artifact. However, an active Icon Artifact.png Artifact will not prevent the addition of the cards.

Player Interactions[]

  • Flex's Icon Strength.png Strength loss at the end of turn is handled as a Debuff that can be negated by Icon Artifact.png Artifact, making the Icon Strength.png Strength gain permanent.
  • Icon WraithForm.png Wraith Form and Icon Bias.png Biased Cognition's Debuffs can be negated by Icon Artifact.png Artifact before you played mentioned cards. If you gain Icon Artifact.png Artifact after being inflicted by the Debuffs, it will negate 1 tick of their respective effects.
  • No Draw from Bullet Time or Battle Trance can be negated, allowing the player to keep on drawing cards.
  • The downsides of Panic Button, Hyperbeam, Berserk, and Fasting can be negated, allowing them to be played safely.
  • Blasphemy's effect is considered a buff, preventing Icon Artifact.png Artifact from blocking it.



Defect Cards[]

Neutral Cards[]




Update History[]

  • Weekly Patch 50: The Final Act
    • Turnip and Ginger relics now prevent Artifact from triggering when they nullify Debuffs.
  • Weekly Patch 40: Forethought
    • Shifting Power (Transient) should now interact correctly, even if the owner has Artifact.
  • Weekly Patch 35: Aggregate
    • Corpse Explosion power is now a Debuff.
  • Weekly Patch 33: Terror
    • No Draw power now counts as a Debuff.
    • Wraith Form power now properly counts as a Debuff. (Like Biased Cognition)